Endocrine Abstracts

Obesity caused by excess energy intake has been emerging as a major health concern in the world, with increased risk leading to diabetes, hypertension, nephropathy, and cardiovascular disease. A better understanding of the molecular mechanism on how obesity develops is of critically clinical importance. Accumulating data suggest that ER-stress is strongly related with development of obesity, implying that ER stress can be a therapeutically target of obesity. 4-Phenylbutyrate (...